Table 4.

Univariate and multivariate COX analysis predicting for cardiovascular outcomes (a composite of 54 fatal and non-fatal events)

	Crude analysis		Terminal Model
ADMA (μmol/l)	1.36 (1.18-1.56)	<0.001	1.31 (1.13-1.52)	<0.001
TG/HDL-C ratio	1.56 (1.29-1.90)	<0.001	1.36 (1.11-1.67)	0.003
History of Diabetes (Yes/No)	4.91 (2.85-8.44)	<0.001	4.82 (2.80-8.37)	<0.001

Represented are Hazard Ratios (and 95% confidence intervals) in univariate (crude) Cox model and after systematic adjustments. Saturated model at first step include age (in years). Sex (women as reference). eGFR (in ml/min). hsCRP, FMD, calcium, phosphate, PTH, smoking, serum albumin, total cholesterol, triglyceride, LDL-cholesterol, HDL-cholesterol, SBP, DBP, HOMA-IR, ADMA, diabetes (absence as reference) and medical history of cardiovascular disease (absence as reference) at baseline.

FMD. Flow mediated dilatation; hsCRP. High sensitivity C reactive protein; eGFR. Estimated glomerular filtration rate.