Table 3.
Agreement for Tests of Mycobacterium tuberculosis Infection and Discordance between Tests Stratified by HIV Status in Children
| TST versus TSpot Discordant Results |
TST versus QFT Discordant Results |
TSpot versus QFT Discordant Results | |||||||
|---|---|---|---|---|---|---|---|---|---|
| TSpot +ve TST −ve [n/N (%)] | TSpot −ve TST +ve* [n/N (%)] | κ (95% CI) | QFT +ve TST −ve [n/N (%)] | QFT −ve TST +ve* [n/N (%)] | κ (95% CI) | TSpot +ve QFT −ve [n/N (%)] | TSpot −ve QFT +ve [n/N (%)] | κ (95% CI) | |
| Baseline measures | |||||||||
| All children | 42/983 (4.3) | 108/983 (11.0) | 0.66 (0.61–0.71) | 85/1,246 (6.8) | 79/1,246 (6.3) | 0.73 (0.69–0.77) | 23/940 (2.4) | 72/940 (7.7) | 0.78 (0.73–0.82) |
| Children infected with HIV | 4/259 (1.5) | 49/259 (18.9) | 0.45 (0.33–0.56) | 12/267 (4.5) | 41/267 (15.4) | 0.50 (0.38–0.61) | 5/245 (2.0) | 19/245 (7.8) | 0.68 (0.56–0.80) |
| Children not infected with HIV | 38/724 (5.2) | 59/724 (8.2) | 0.71 (0.66–0.77) | 73/979 (7.5) | 38/979 (3.9) | 0.77 (0.73–0.81) | 18/695 (2.6) | 53/695 (7.6) | 0.78 (0.74–0.83) |
| Composite measures† | |||||||||
| All children | 38/1,052 (3.6) | 111/1,052 (10.6) | 0.70 (0.66–0.75) | 83/1,310 (6.3) | 97/1,310 (7.4) | 0.72 (0.68–0.76) | 29/1,046 (2.8) | 73/1,046 (7.0) | 0.79 (0.76–0.83) |
| Children infected with HIV | 8/287 (2.8) | 56/287 (19.5) | 0.46 (0.36–0.57) | 14/290 (4.8) | 50/290 (17.2) | 0.49 (0.38–0.59) | 11/287 (3.8) | 23/287 (8.0) | 0.66 (0.56–0.77) |
| Children not infected with HIV | 30/765 (3.9) | 55/765 (7.2) | 0.77 (0.73–0.82) | 66/1,020 (6.8) | 47/1,020 (4.6) | 0.77 (0.73–0.81) | 18/759 (2.4) | 50/759 (6.6) | 0.82 (0.78–0.86) |
Definition of abbreviations: +ve = positive; −ve = negative; CI = confidence interval; QFT = QuantiFERON-TB Gold In-Tube; TSpot = T-SPOT.TB; TST = tuberculin skin test.
*
TST greater than or equal to 10 mm was considered as positive for participants uninfected with HIV and TST greater than or equal to 5 mm for participants infected with HIV.
†
M. tuberculosis infection status defined considering both baseline and 3-month test results. A child was defined as infected by a specific test if positive at either baseline or 3 months.