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. Author manuscript; available in PMC: 2015 Apr 23.
Published in final edited form as: J Mol Biol. 2013 Jan 25;425(9):1461–1475. doi: 10.1016/j.jmb.2013.01.027

Figure 6. Temperature dependence of AChR gating.

Figure 6

a. The slope of the van’T Hoff plot (ΔG2 vs. 1/T) is agonist-dependent 86. b. The enthalpy change (black bars) associated with most mutations is larger than the free energy change (white bars) because of a compensating entropy change. c. An example where enthaply changes of mutations are approximately additive.