Table 2.
Main dilated cardiomyopathy-causing genes hypertrophic cardiomyopathy.
| Gene | Protein | OMIM | % of familial HCM cases |
|---|---|---|---|
| MYH7 | Myosin heavy chain | 160760 | 40% |
| Cardiac muscle beta isoform | 192600 | ||
|
| |||
| MYBPC3 | Myosin-binding protein C, cardiac-type | 600958 | 40% |
|
| |||
| TNNT2 | Troponin T, cardiac muscle | 115195 | 5% |
|
| |||
| TNNI3 | Troponin I, cardiac muscle | 191044 | 5% |
|
| |||
| TPM1 | Tropomyosin 1 alpha chain | 115196 | 2% |
| 191010 | |||
|
| |||
| MYL2 | Myosin regulatory light chain 2 | 160781 | Unknown |
| ventricular/cardiac muscle isoform | 608758 | ||
|
| |||
| MYL3 | Myosin light polypeptide 3 | 160790 | 1% |
| 608751 | |||