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. 2015 Apr 2;12:27. doi: 10.1186/s12950-015-0074-3

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© Chang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison of lumen cross-sectional areas of the basilar artery. Top panel: representative micrographs of the cross-section of basilar artery obtained from the sham operated rat (A), SAH only animals (B), the vehicle-treated SAH rats (C), SAH rat treated with 10 mg/kg/day valproic acid (VPA) (D), 20 mg/kg/day VPA treatment SAH rats (E) and 40 mg/kg/day VPA treatment in SAH animals (F). Standard bar = 200 μm. Bottom panel: quantification of the lumen cross-sectional areas. All values are mean ± SD (n = 9). Valproic acid, in 40 mg/kg/day, exerted a potential to alleviate the vasospastic response when compared with the vehicle + SAH group. *, **, ***: P < 0.01 compared with the SAH group.