Table 1.
Baseline demographic, clinical, and imaging characteristics of the placebo group according to the absence or presence of meniscal extrusion
| Ext- (n = 86) | Ext+ (n = 26) | P -value | |
|---|---|---|---|
| Demographic and clinical | |||
| Age, years | 62 ± 8 | 65 ± 8 | 0.078 |
| Female, n (%) | 57 (66%) | 19 (73%) | 0.515† |
| Body mass index, kg/m2 | 30 ± 4 | 29 ± 6 | 0.275 |
| WOMAC | |||
| Pain (0 to 100) | 37.7 ± 21.9 | 40.9 ± 20.0 | 0.340 |
| Function (0 to 100) | 39.5 ± 22.4 | 38.3 ± 22.7 | 0.762 |
| Stiffness (0 to 100) | 41.9 ± 24.5 | 46.4 ± 19.4 | 0.403 |
| Total (0 to 300) | 120.6 ± 65.0 | 127.1 ± 56.6 | 0.654 |
| VAS pain (0 to 100 mm) | 48.5 ± 25.2 | 54.3 ± 18.8 | 0.199 |
| Imaging | |||
| Kellgren-Lawrence score, n (%) | 0.002 † | ||
| Grade 1 | - | - | |
| Grade 2 | 64 (74%) | 11 (42%) | |
| Grade 3 | 22 (26%) | 15 (58%) | |
| Joint space width, mm | 3.61 ± 0.77 | 3.15 ± 0.51 | 0.004 |
| Presence of BML in the medial compartment, n (%) | 18 (21%) | 12 (46%) | 0.011 † |
| MRI, mm3 | |||
| Global knee | 11256 ± 2968 | 10479 ± 2243 | 0.395 |
| Femur | 7773 ± 2139 | 7398 ± 1465 | 0.697 |
| Plateau | 3483 ± 897 | 3081 ± 830 | 0.109 |
| Medial compartment | 5324 ± 1435 | 5089 ± 1020 | 0.682 |
| Medial femur | 3763 ± 1023 | 3619 ± 689 | 0.817 |
| Medial plateau | 1562 ± 452 | 1470 ± 360 | 0.608 |
Results are shown as mean ± SD unless otherwise indicated. † P-values obtained using the chi-square test. All other P-values were obtained using the Kruskal-Wallis test. Statistically significant P-values are in bold. Ext, meniscal extrusion; n, number of participants; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (each subscale, 100 = worst score; total scale, 300 = worst score). ; VAS, visual analog scale (0 mm= no pain, 100 mm= most severe pain); MRI, magnetic resonance imaging; BML, bone marrow lesions.