Table 2.

Impact of co-colonization of Hi or Mcat with Spn on serum antibody responses to Spn.

	Culture negativeGM (95% CI, n)	SpnGM (95% CI, n)	Spn + HiGM (95% CI, n)	Spn + McatGM (95% CI, n)
IgA (μg/ml)
Anti-PhtD	0.10**** (0.058–0.178, 118)	0.68 (0.400–1.158, 80)	1.97* (0.897–4.396, 29)	2.07** (1.155–3.712, 65)
Anti-PcpA	0.098**** (0.057–0.170, 118)	1.13 (0.716–1.771, 81)	1.765 (0.894–3.486, 29)	2.232* (1.299–3.835,65)
Anti-PlyD1	0.02** (0.015–0.040, 118)	0.07 (0.043–0.117, 81)	0.143* (0.066–0.308, 29)	0.15* (0.091–0.247, 64)
Anti-whole cell	0.07*** (0.055–0.092, 125)	0.14 (0.113–0.178, 100)	0.22* (0.144–0.328, 45)	0.22** (0.171–0.282, 115)
IgG (μg/ml)
Anti-PhtD	4.86*** (3.55–6.66, 117)	10.64 (7.726–14.673, 81)	15.42 (8.931–26.616, 29)	18.66* (12.597–27.644, 65)
Anti-PcpA	3.83**** (2.524.5–5.819, 102)	13.80 (10.040–18.971, 78)	17.48 (10.332–29.563, 27)	24.73* (17.115–35.331, 55)
Anti-PlyD1	0.38** (0.242–0.597, 103)	1.10 (0.753–1.604, 76)	2.03 (1.050–3.907, 27)	2.96*** (1.969–4.455, 55)
Anti-whole cell	3.51*** (2.840–4.331, 116)	6.17 (5.105–7.449, 95)	6.90 (5.096–9.336, 42)	6.16 (5.029–7.546, 107)

Spn, S. pneumoniea; Hi, H. influenzae; Mcat, M. catarrhalsi. GM, geometric mean; CI, confidence interval.

^*P < 0.05 compared with sole Spn.

^**P < 0.01 compared with sole Spn.

^***P < 0.001 compared with sole Spn.

^****P < 0.0001 compared with sole Spn.