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. 2015 Apr 23;6:76. doi: 10.3389/fphar.2015.00076

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Copyright © 2015 Weissinger, Borchers, Silvani, Provasi, Radrizzani, Beckmann, Benati, Schmidtke, Kuehnau, Schweier, Luther, Fernandez-Munoz, Beutel, Ciceri, Bonini, Ganser, Hertenstein and Stadler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical trial flow chart. Prior to G-Lymphapheresis were obtained prior to G-CSF-stimulation of the donor and shipped to MolMed for transduction by courier. After G-CSF-stimulation peripheral blood stem cells (PBSCs) were collected and CD34⁺ cells were selected and transplanted on day 0. The recipient of matched related donor PBSC received conditioning treatment with total body irradiation (TBI; 12 Gy) and cyclophosphamide (120 mg) and ATG (30 mg/kg). The recipients of the mismatched related donor PBSC received conditioning with Fludarabine, Melphalan, Thiotepa, and anti-thymoglobulin (ATG; 60 mg/kg). Lymphapheresis cells were transduced with SCFMM3 , and shipped to Hannover prior transfusion. HSV-TK DLI (1 × 10⁷ cells/kg BW) were administered either after day +60 (MRD) or on day +42 (MMRD; 1 × 10⁶/kg BW).