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Influence of HSP27 overexpression on the cellular sensitivity towards DR-targeting agents. (A and B) Proliferation assays comparing the sensitivity of parental PL5 and empty vector-transfected (PL5/EV) control cells versus two independently derived HSP27-overexpressing cell clones (PL5/hu16, PL5/hu18) towards DR5-agonistic antibodies tigatuzumab (A) or LBY135 (B), respectively at the indicated concentrations. Error bars represent SEM of at least three independent experiments.
