Fig 3.
Renal infiltration of leucocytes and macrophages after kidney damage and EGF and P-GCSF treatments. Immunohistochemistry for (A) CD45 and (B) F4/80 reveals clusters of infiltrated leucocytes and macrophages respectively 4 days after induction of acute kidney injury in a female recipient of male BM. This mouse was treated with HgCl2 and EGF, but without P-GCSF treatment. (C) In mice with renal damage, P-GCSF increased the abundance of CD45-positive cells in the kidney (10.46 ± 0.44% versus 0.8 ± 0.04%, P < 0.001). EGF injections did not affect the abundance of CD45-positive cells.