Fig 6.

The effects of acute kidney injury, EGF and P-GCSF on the proportion of proximal tubular cell proliferation of BM-origin and on S-Phase status. (A) Acute kidney injury increased the proportion of proximal tubule cells derived from BM irrespective of treatment with EGF and/or P-GCSF, thus scoring of these cells was not affected by the influx of CD45 cells after P-GCSF. (B) The proportion of proximal tubule cells in S-phase was increased by acute kidney injury and EGF synergistically, whereas P-GCSF was without effect. (C) Indigenous proximal tubule cells responded to acute kidney injury and more so in combination with EGF, whereas P-GCSF had no effect on S-phase status. (D) A small but statistically significant increase occurred in the proportion of exogenous (BM-derived) proximal tubule cells in S-phase, with no effect of EGF or P-GCSF. Differences from corresponding control groups: ***P < 0.001. Means ± SEM, n = 5.