Table 2.
Selected functions modulated by the identified genes
| Function category (no of molecules) | P-value | Functions of interest | Selected genes for further validation |
|---|---|---|---|
| Cell death and survival (178 molecules) | 8.83E−11–7.5E−3 | Cell death, apoptosis, cell survival | NRAS, CYR61, EDN1, IL15, NRG1, LGALS3, PLAUR, LRIG1, CSF2, DKK1, DNAJA1, HIPK3, EMP2, THG1L, ILF3 |
| Tissue development (104 molecules) | 2.4E−9–6.8E−3 | Development of epithelial, endothelial tissues, endothelial cell development and proliferation, adhesion of epithelial cells, tubulation of epithelial tissue, detachment of cells | NRAS, CYR61, EDN1, IL15, NRG1, LGALS3, PLAUR, CSF2, DKK1 |
| Cellular growth and proliferation (174 molecules) | 2.75E−8–7.56E−3 | Tumour and endothelial cell proliferation | NRAS, CYR61, EDN1, IL15, NRG1, LGALS3, PLAUR, LRIG1, CSF2, DKK1, DNAJA1, MYCBP, PGK1, EMP2, THG1L, ILF3 |
| Cardiovascular system development and function (84 molecules) | 3.71E−8–6.76E−3 | Endothelial cell development and proliferation, development of blood vessels, cell movement of endothelial cells | NRAS, CYR61, EDN1, IL15, NRG1, LGALS3, PLAUR, CSF2, DKK1, PGK1 |
| Cellular development (150 molecules) | 5.8E−7–7.56E−3 | Development of epithelial, endothelial cells | NRAS, CYR61, EDN1, IL15, NRG1, LGALS3, PLAUR, LRIG1, CSF2, DKK1, MYCBP, PGK1 |
| Organismal development (121 molecules) | 5.8E−7–7.97E−3 | Development of endothelial cells and blood vessels | NRAS, CYR61, EDN1, IL15, NRG1, LGALS3, PLAUR, LRIG1, CSF2, DKK1,DNAJA1, PGK1,ILF3 |
| Cell-to-cell signalling and interaction (61 molecules) | 1.01E−6–7.84E−3 | Adhesion of epithelial and endothelial cells | NRAS, CYR61, EDN1, IL15, LGALS3, PLAUR, CSF2, DKK1 |
| Cell morphology (119 molecules) | 1.82E−6–6.76E−3 | Tubulation of cells | NRAS, CYR61, EDN1, IL15, NRG1, LGALS3, PLAUR, CSF2, DNAJA1 |
| Cellular movement (96 molecules) | 3.8E−5–7.99E−3 | Tumour cell movement, invasion of cells, migration of tumour and endothelial cells | NRAS, CYR61, EDN1, IL15, NRG1, LGALS3, PLAUR, LRIG1, CSF2, DKK1, DNAJA1 |