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. 2015 Apr 23;6:52. doi: 10.3389/fendo.2015.00052

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Copyright © 2015 Galea, Hannuna, Meakin, Delisser, Lanyon and Price.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ovariectomy and aging on the eccentricity of the mouse tibia at each site along the bone’s length. (A) Representative binarized images of the cross-sections through the 75% site of the tibia from a young control mouse, an ovariectomized mouse, and an aged mouse. (B,C) Eccentricity calculated from left tibiae of (B) non-ovariectomized control mice and left tibiae from ovariectomized mice or (C) young or aged mice, n = 6. Dots/bars above the graphs indicate sites of significant difference, p < 0.05 following Bonferroni correction. Interactions are the site by ovariectomy interactions calculated by mixed models; *p < 0.05, ***p < 0.001.