Table 6.

Recent Ocular Prodrug Patents

Inventor	Drug	Promoiety	Disease	United States Patent
Allergan	Dexamethasone, bimatoprost	amino acid, peptide, monocar- boxylic acid, organic anion, cation nucleoside	posterior segment eye disease	7714024 [188]
Allergan	anti-glaucoma, ocular hy- potensive compounds	acetylcholinester, psuedoacetylcholine	glaucoma	6350780[189]
University of Georgia Research Foundation	etoposide, vincristine, fluo- cinolone and other steroids	carotenoid (zeaxanthine)	macular and retinal disease	20070259843[190]
Novagali Pharnia SA	steroids	lipophilic ester	posterior segment eye disease	20070280995[191]
University of Florida and University of North Texas Health Science Center	steroidal quinol compounds	phosphate or tertiary amide ester	cataract or glaucoma	7572781 [192]
University of Missouri Kansas City	acyclovir and ganciclovir	dipeptide, tripeptide ester	herpes virus infection	WO 2003/03048190
University of Missouri Kansas City	nucleoside, nucleotide, oligonucleotide, peptide	lipophilic linker	ocular diseases	WO 2009/158633 A1
Cellgate, Inc.	anti-bacterial, anti-viral, anti-fungal	guanidine, amidino, arginine	ocular infections	7229961[193]