Table 3.
No | Method of preparation | Drug | pH | Particle size (nm) |
---|---|---|---|---|
(a) Particle size of Fab:DS HIP NPs with respect to pH | ||||
1 | Nanoprecipitation method | Fab:DS HIP | 7.45 | 222.10 ±5.54 |
6 | 217.55 ±0.97 | |||
5 | 216.05 ± 1.77 | |||
4 | 284.70 ±9.41 | |||
2 | S/O/W method | Fab:DS HIP | 7.45 | 171.90 ±3.87 |
6 | 174.40 ±2.77 | |||
5 | 175.47 ±3.23 | |||
4 | 173.90 ±2.17 | |||
(b) Zeta potential of Fab:DS HIP NPs with respect to pH. | Zeta potential (mV) | |||
|
||||
1 | Nanoprecipitation method | Fab:DS HIP | 6 | −10.25 ± 0.07 |
4 | −3.63 ±0.09 | |||
2 | S/O/W method | Fab:DS HIP | 6 | −5.47 ± 1.68 |
4 | −4.80 ±0.66 |
Note: Values are represented as mean ± SD (n = 3).