Fig. 5.

Evolution of sEH inhibitors. Over the past decade, sEH inhibitors have evolved with increased potency, increased PK-ADME, and multiple target engagement. From this development, AUDA has been investigated in human clinical trials (Tran et al., 2012) and second-generation inhibitors have been optimized to IND candidates. PTUPB, 4-(5-phenyl-3-{3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl}-pyrazol-1-yl)benzenesulfonamide; TUPS, 1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)urea.