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Differential regulation of CYP2B6 and CYP3A4 by GW4064. FXR activation by GW4046 leads to decreased CYP3A4 expression, potentially through SHP upregulation and subsequent repression of PXR and CAR transactivation of CYP3A4 promoter. On the other hand, GW4064 enhances CYP2B6 promoter activity.
