Fig. 7.

Structural alignment of glucocorticoids clobetasol propionate (orange) and dexamethasone (gray). Clobetasol propionate, a potent MRP4 inhibitor, inhibits MRP4-mediated transport of DHEAS by 101 ± 23%. In contrast, dexamethasone exhibits no significant inhibitory effect (5 ± 34% inhibition). The orange circles indicate identical chemical groups in proximity with each other. On the stick model, red represents oxygen atoms, green represents halogen atoms, and the rest represents carbon atoms.