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. 2015 May;353(2):369–379. doi: 10.1124/jpet.114.220368

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Fig. 5. — JWH-133 treatment causes a differential expression of a number of miRNAs in liver MNCs that can potentially regulate TLR signaling pathway. Mice were treated with LPS+vehicle or LPS+JWH-133 as described in Fig. 1, and liver MNCs were isolated for each group as described in Materials and Methods. (A) Heat map for the expression of 2023 miRNAs, with the first two lanes showing LPS+JWH-133 treatment and the latter two lanes showing LPS+vehicle treatment. (B) Gene ontology analysis of the predicted target genes of miRNAs identifies the major cellular pathways altered in the JWH-133+LPS group as compared with the LPS+vehicle group. A pie chart (C) and bar graph analysis (D) of the major cellular pathways altered in the JWH-133+LPS group when compared with the LPS+vehicle based on miRNAs altered by more than 1.5-fold.

Fig. 5. — JWH-133 treatment causes a differential expression of a number of miRNAs in liver MNCs that can potentially regulate TLR signaling pathway. Mice were treated with LPS+vehicle or LPS+JWH-133 as described in Fig. 1, and liver MNCs were isolated for each group as described in Materials and Methods. (A) Heat map for the expression of 2023 miRNAs, with the first two lanes showing LPS+JWH-133 treatment and the latter two lanes showing LPS+vehicle treatment. (B) Gene ontology analysis of the predicted target genes of miRNAs identifies the major cellular pathways altered in the JWH-133+LPS group as compared with the LPS+vehicle group. A pie chart (C) and bar graph analysis (D) of the major cellular pathways altered in the JWH-133+LPS group when compared with the LPS+vehicle based on miRNAs altered by more than 1.5-fold.