TABLE 1.
Dissociation binding constant, Kd (nM), and total number of binding sites, Bmax (pmol/mg), of PD-Svg or PS-Svg radioligand determined from saturation binding to either CRF1 or CRF2(b) receptor
The data are mean ± S.E.M.; n = 3 per cell.
| PD-Svg Radioligand Kd | PS-Svg Radioligand Kd | PD-Svg Radioligand Bmax | PS-Svg Radioligand Bmax | |
|---|---|---|---|---|
| CRF1 | 0.48 ± 0.07 | 0.49 ± 0.27 | 6.8 ± 0.37 | 0.5 ± 0.08 |
| CRF2(b) | 0.20 ± 0.03 | 0.41 ± 0.09 | 12.3 ± 0.2 | 4.2 ± 0.4 |