. 2015 May;353(2):307–317. doi: 10.1124/jpet.114.222307

TABLE 2.

Inhibitory binding constants, K_i (nM), of representative CRF family ligands determined by competitive binding of PD-Svg or PS-Svg radioligands bound to either CRF₁ or CRF_2(b) receptor

Ranges given in parentheses correspond to 95% confidence limits; n = 3–6 per cell. Data reproduced from previous publications are indicated

	PD-Svg	PS-Svg	r/hCRF	rUcn 1	mUcn 2	mUcn 3	Astressin
PD-Svg radioligand bound to either CRF₁ or CRF_2(b) receptors
CRF₁	4.4 (2.9–6.5)	62 (29–140)	19 (7–49)	3.0 (2.0–4.5)	>300	>300	0.47 (0.42–0.52)
CRF_2(b)	1.9 (1.3–2.7)	28 (21–40)	13 (2–16)	4.3 (3.7–4.9)	4.8 (3.3–7.0)	120 (100–140)	0.7 (0.2–3)
PS-Svg radioligand bound to either CRF₁ or CRF_2(b) receptors
CRF₁	0.22 (0.18–0.27)	0.75 (0.59–0.94)	1 (0.2–5)^a	0.32 (0.14–0.77)^b	>100^b	>100^b	0.7 (0.3–2)^a
CRF_2(b)	0.40 (0.38–0.42)	3.6 (2.5–5.1)	6 (2–20)^a	0.6 (0.1–3)^b	0.7 (0.1–3)^b	2 (0.8–4)^b	0.62 (0.49–0.78)^a

h, human; m, mouse; r, rat.

^{^a}

From Rivier et al. (2002).

^{^b}

From Lewis et al. (2001).