TABLE 3.
Inhibitory binding constant, Ki (nM), of representative CRF family ligands determined by competitive binding of astressin radioligand bound to either CRF1 or CRF2(b) receptor
Ranges given in parentheses correspond to 95% confidence limits; n = 3 per cell.
| PD-Svg | PS-Svg | Astressin | |
|---|---|---|---|
| CRF1 | 9 (3–28) | 100 (50–200) | 2.3 (1.9–2.9) |
| CRF2(b) | 2.8 (2.5–3.2) | 21 (19–23) | 1.3 (0.6–2.6) |