TABLE 4.

EC₅₀ (nM) values of representative CRF family ligands for stimulation of intracellular accumulation of cAMP in AtT-20 or A7r5 cells, which express CRF₁ or CRF_2(b) receptors, respectively

Ranges given in parentheses correspond to 95% confidence limits. n = minimum 3 per cell.

	PD-Svg	PS-Svg	r/hCRF	rUcn 1	mUcn 2	mUcn 3
AtT-20	0.18 (0.14–0.24)	1.45 (1.2–1.8)	1.5 (1.4–1.7)	0.5 (0.47–0.53)	N.D.	N.D.
A7r5	0.04 (0.02–0.07)	0.30 (0.16–0.58)	N.D.	0.06 (0.03–0.12)	0.06 (0.03–0.14)	0.30 (0.16–0.58)

h, human; m, mouse; N.D., not determined; r, rat.