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. 2015 May;87(5):878–889. doi: 10.1124/mol.115.097782

Fig. 4.

Fig. 4.

CINPA1 is not cytotoxic within the concentration range effective for modulating CAR and PXR. (A) HepG2 cells were transfected with hCAR1 and CYP2B6-luc plasmid to mimic conditions used in the luciferase screening assays. Cells were treated with indicated compounds for 24 hours, and viability was measured by using CellTiter Glo reagent. Rif, rifampicin. No significant change was observed between treatments. (B) HepG2. (C) LS174T. (D) HEK293T cells were treated with DMSO (control), CINPA1, CLZ, or PK11195 at the indicated concentrations. Cell viability was measured 4 days posttreatment by using CellTiter Glo reagent. Viability of cells treated with DMSO (negative control) was set to 100% in all assays.