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. 2015 May;87(5):855–864. doi: 10.1124/mol.114.096511

TABLE 2.

IC₅₀ and Hill coefficients for α-CTx RgIA on rat α10 mutant receptors

nAChR Mutation	IC₅₀ (nM) RgIA (95% CI)	Hill Coefficient
α9α10	1.49 (1.13–1.95)	1.24 ± 0.19
α9α10E61I	2.0 (1.24–3.21)	0.78 ± 0.12
α9α10E61T	3.54 (2.81–4.47)	1.17 ± 0.13
α9α10D121L	1.36 (1.19–1.61)	1.14 ± 0.09
α9α10E197Q^a	37.5 (26.6–52.8)^a	1.17 ± 0.15
α9α10P200Q^a	466 (176–1230)^a	0.55 ± 0.13

^{^a}

Mutations making the greatest difference in toxin potency.