TABLE 3.

EC₅₀ for ACh dose-response curves on α9 and α10 mutants that affected α-CTx RgIA potency

Values are mean ± S.E.M. from at least three different oocytes.

nAChR	ACh EC50 (95% CI) μM	Hill Slope
α9α10	10.1 (8.68–11.8)	1.2 ± 0.1
α9T61Iα10	10.7 (8.90–12.9)	1.4 ± 0.2
α9D121Lα10	323 (238–437)	1.8 ± 0.4
α9α10E197Q	193 (145–257)	0.54 ± 0.04
α9α10P200Q	419 (369–477)	0.81 ± 0.04