Figure 6. Alteration in the composition of DNA-binding AP-1 complex A. untreated cells B. curcumin-treated cells. Supershift analysis using nuclear extracts (10 ug) from oral cancer cells incubated with specific antibodies (2 ug each lane) either against AP-1 members C. Dose kinetics of curcumin in different concentrations (0–100 uM) on AP-1 trans-activation showing modified DNA binding D. Time kinetics of curcumin on AP-1 trans-activation at different time intervals (0–2 hr). UT = Untreated.
