Figure 1.

Cardiorespiratory fitness is associated with markers of glycemic control. VO_2max was measured during incremental workload and exhaustive aerobic exercise in subjects representative of a heterogeneous population with respect to age, BMI, adiposity, and glucose tolerance status (white circles, NGT; light-gray squares, IGT; and dark-gray triangles, T2D). Regression analysis demonstrated inverse curvilinear log-log relationships between VO_2max and HbA_1c (log₁₀y = −0.14 log₁₀x + 0.98) (A), fasting glucose (log₁₀y = −0.17 log₁₀x + 1.03) (B), and 2-h glucose during OGTT (log₁₀y = −0.39 log₁₀x + 1.55) (C). Solid and dotted lines represent the regression curves and 95% CI, respectively, and show unadjusted data.