Table 2.

Relationships between VO_2max and OGTT-derived variables

	NGT		IGT		T2D		All subjects
	r	P	r	P	r	P	r	P
Glycemic control
HbA1c (%)	−0.392	<0.0001	−0.217	ns	−0.015	ns	−0.333	<0.0001
Fasting plasma glucose (mmol/L)	−0.475	<0.0001	−0.288	<0.05	−0.175	ns	−0.336	<0.0001
2-h OGTT plasma glucose (mmol/L)	−0.436	<0.0001	−0.343	<0.001	−0.097	ns	−0.325	<0.0001
SiOGTT (µmol/kg/min/pmol ⋅ L)	0.733	<0.0001	0.609	<0.0001	0.525	<0.0001	0.734	<0.0001
GSISOGTT (AUC C-peptide [pmol/L ⋅ min])
Early phase	−0.325	<0.001	−0.309	<0.05	−0.233	<0.05	−0.336	<0.0001
Late phase	−0.406	<0.0001	−0.312	<0.05	−0.166	ns	−0.361	<0.0001
DIOGTT (arbitrary units)
Early phase	0.399	<0.01	0.361	<0.01	0.390	<0.01	0.405	<0.0001
Late phase	0.404	<0.01	0.360	<0.01	0.354	<0.01	0.411	<0.0001

In a cohort representative of the whole glucose tolerance continuum, we determined whether statistically significant associations existed between cardiorespiratory fitness (VO_2max) (mL/kg/min) and HbA_1c (total N = 218; n = 102 NGT, n = 47 IGT, and n = 69 T2D), fasting glucose and 2-h OGTT (total N = 313; n = 137 NGT, n = 85 IGT, and n = 91 T2D), Si_OGTT (total N = 304; n = 134 NGT, n = 83 IGT, and n = 87 T2D), GSIS_OGTT (total N = 240; n = 111 NGT, n = 54 IGT, and n = 75 T2D), and DI_OGTT (total N = 235; n = 110 NGT, n = 53 IGT, and n = 72 T2D). Data indicate correlation coefficients (r) for comparisons between variables. AUC, area under the curve.