Table 3.

Multiple regression analyses

Independent variables	HbA1c (R2 = 0.20)				FPG (R2 = 0.15)				2-h OGTT glucose (R2 = 0.22)				SiOGTT (R2 = 0.86)
	B	SE B	β	P	B	SE B	β	P	B	SE B	β	P	B	SE B	β	P
Constant	11.29	1.04		5.8 × 10−22	14.06	1.66		1.3 × 10−15	37.02	4.20		1.1 × 10−16	0.08	0.007		2.4 × 10−24
VO2max	−0.06	0.01	−0.83	4.8 × 10−9	−0.10	0.02	−0.68	3.7 × 10−8	−0.32	0.04	−0.87	7.3 × 10−13	0.0005	0.00007	0.34	1.1 × 10−10
Age	−0.02	0.01	−0.29	0.001	−0.02	0.01	−0.17	0.04	−0.08	0.03	−0.21	0.006	0.0002	0.00005	0.13	7.6 × 10−5
Sex	−0.30	0.21	−0.16	0.15	−1.03	0.32	−0.32	0.002	−2.84	0.82	−0.34	0.0006	0.007	0.001	0.20	4.0 × 10−6
Weight	−0.03	0.01	−0.43	0.006	−0.04	0.01	−0.41	0.003	−0.12	0.03	−0.48	0.0003	0.0001	0.00006	0.13	0.02
BMI	0.04	0.03	0.25	0.14	0.09	0.04	0.30	0.05	0.18	0.11	0.23	0.10	−0.003	0.0002	−0.81	1.5 × 10−31
Fat %	−0.02	0.01	−0.29	0.03	−0.04	0.02	−0.29	0.01	−0.10	0.04	−0.26	0.02	−0.0001	0.00007	−0.09	0.05
	Early-phase GSISOGTT (R2 = 0.18)				Late-phase GSISOGTT (R2 = 0.18)				Early-phase DIOGTT (R2 = 0.33)				Late-phase DIOGTT (R2 = 0.32)
Independent variables	B	SE B	β	P	B	SE B	β	P	B	SE B	β	P	B	SE B	β	P
Constant	29,034	14,130		0.04	195,511	100,528		0.05	3,130	770		0.0001	18,623	5,346		0.0006
VO2max	−6,057	2,278	−0.32	0.008	−31,946	16,306	−0.24	0.03	16.8	8.0	0.22	0.04	96.7	55.5	0.23	0.04
Age	−240	126	−0.16	0.06	−1,339	899	−0.13	0.14	−1.1	5.2	−0.02	0.84	33.6	36.3	0.08	0.36
Sex	1,644	4,057	0.05	0.69	−4,922	28,840	−0.02	0.87	172	163	0.11	0.29	513	1133	0.05	0.65
Weight	538	166	0.51	0.001	2,574	1178	0.35	0.03	17.3	6.4	0.38	0.007	83.4	44.4	0.26	0.06
BMI	−223	502	−0.07	0.66	−649	3,571	−0.03	0.86	−121	21	−0.90	1.4 × 10−8	−785	142	−0.85	9.4 × 10−8
Fat %	−23	220	−0.02	0.92	1,640	1,579	0.16	0.30	10.9	9.4	0.17	0.25	132	66	0.30	0.05

In a cohort representative of the whole glucose tolerance continuum, we determined the relative contributions of VO_2max and other independent variables such as age, sex, body weight, BMI, and whole-body fat percentage to the variance of glycemic control (HbA_1c, fasting glucose [FPG], 2-h OGTT glucose), Si_OGTT, GSIS_OGTT, and DI_OGTT using a forced-entry multiple regression method. Dependent variables are the actual values and not log transformed. The statistical significance of β values is indicated by the individual P values. B, the unstandardized β, which represents the change in the dependent variable resulting from 1 unit change in the independent variable; SE B, the SE of β; β, standardized β, which represents the change in the dependent variable resulting from 1 SD change in the independent variable.