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. 2014 Dec 9;211(10):1597–1606. doi: 10.1093/infdis/jiu664

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© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Cell phenotype and activation in matched blood and cerebrospinal fluid (CSF) at diagnosis of cryptococcal meningitis with immune reconstitution inflammatory syndrome (CM-IRIS). Cell lineages in the CSF and peripheral blood compartments (top panel) and monocyte subsets (middle panel) are shown for 6 subjects at the diagnosis of CM-IRIS. The frequency of natural killer cells (not shown) was similar. Bottom panel shows HLA-DR expression on T cells and programmed death ligand 1 (PD-L1) expression on monocyte subsets.