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Antiviral activity profile of 3b against DENV serotypes
| DENV serotype | EC 50 (μM) a | SI b |
|---|---|---|
| DENV-1 | 26.7 ± 1.8 | >37.3 |
| DENV-2 | 13.5 ± 0.9 | >74.1 |
| DENV-3 | 27.1 ± 2.1 | >36.9 |
| DENV-4 | 12.5 ± 0.8 | >80.0 |
aEffective concentration 50%: compound concentration required to reduce virus yields at 48 h p.i. by 50%. Values are the mean from triplicate independent tests ± standard deviation.
bSelectivity index: ratio CC50/EC50. The CC50 for 3b is > 1000 μM.
