Table 2.
Inflammatory cytokines in critically ill patients before and after a transfusion of fresh frozen plasma (12 ml/kg)
| Before FFP | After FFP | P value | |
|---|---|---|---|
| Proinflammatory parameters (pg/ml) | |||
| TNF-α | 11.3 (2.3–52.3) | 2.3 (2.3–41.0) | 0.01 |
| IL-1β | 15.0 (11.7–18.8) | 14.4 (13.1–23.3) | 0.97 |
| IL-8 | 178 (124–418) | 187 (113–412) | 0.23 |
| MCP-1 | 1255 (503–3376) | 1101 (434–5802) | 0.89 |
| MIP-1A | 19.6 (15.7–33.6) | 19.1 (13.3–34.4) | 0.12 |
| sCD40L | 409 (257–614) | 324 (216–537) | 0.08 |
| Anti-inflammatory parameters (pg/ml) | |||
| IL-1RA | 69.3 (52.1–110.6) | 73.5 (47.8–104.9) | 0.11 |
| IL-10 | 36.1 (15.5–100.1) | 31.5 (14.8–279.6) | 0.62 |
Data expressed as median (IQR). FFP, fresh frozen plasma; TNF-α, tumor necrosis factor alpha; IL-1β, interleukin 1 beta; IL-8, interleukin 8; MCP-1, monocyte chemotactic protein 1; MIP-1A, macrophage inflammatory proteins 1A; sCD40L, soluble CD40 ligand; IL-1RA, interleukin 1 receptor antagonist; IL-10, interleukin 10; IQR, interquartile range.