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. 2015 Apr 24;16:24. doi: 10.1186/s12865-015-0093-0

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© McLaughlin et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Behavior of mice immunized with myelin oligodendrocytic protein (MOG) to induce EAE and treated with OGF or LDN. Behavioral scores of mice immunized with MOG_33–55 and treated daily with either 10 mg/kg OGF (OGF) or 0.1 mg/kg naltrexone (LDN); control mice received intraperitoneal injections of 0.1 ml saline (saline). Mice were evaluated daily and scored (0–10 scale) by multiple observers, with one masked to treatment. Values represent means ± SEM; N = 5 or 6 mice/group. Significantly different from saline-injected mice at p < 0.05 (*).