Table 1.
Neuroblastoma characteristics and their modulation by TNFα
| MYCN non-amplified [ 36 , 37 ] | MYCN amplified [ 36 , 37 ] | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| SK-N-AS | SK-N-SH | CHLA90 | SH-SY5Y | LAI-5S | SK-N-BE(2) | IMR32 | Tet21N | ||
| Expression | Fas | + | + | +/− | +/− | - | - | + | ++ |
| Caspase-8 | ++ | ++ | +/− | - | +/− | +/− | - | ++ | |
| p53 | N [38] | F [39] | N [40] | F [39] | N [41] | N [40] | F [39] | F [39] | |
| TNFα-induced | Fas | ++ | + | + | - | - | - | - | ++ |
| Sensitization to etoposide/cisplatin | ++ | + | NA | - | - | NA | NA | NA | |
| FasL-induced cell death | UT | + | +/− | - | - | - | - | - | ++ |
| TNFα | +++ | +++ | + | - | - | - | - | +++ | |
Abbreviations: F Functional, N Non-functional, NA Not available.