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. 2015 Apr 18;7(1):46. doi: 10.1186/s13148-015-0082-4

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© Kuasne et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Supervised and unsupervised analysis of gene expression and methylation profiles. (A) Heat map showing 171 significantly hypermethylated probes in the paired analysis of 10 PeCa and SNT samples (P value ≤0.001 and FDR ≤0.05). (B) Volcano plot of the methylated regions: left-sided deviation indicates that all hypermethylated probes were tumor related. (C) Unsupervised analysis showing dendogram and heat map of altered transcripts from the gene expression analysis in PeCa. (D) Unsupervised analysis showing dendogram and heat map of altered probes from the methylation analysis in 25 PeCa samples. Rectangles show clinical characteristics of patients with PeCa. Numbers below rectangles represent samples.