Figure 7. Langerhans cells mediate IL-17 response upon S. aureus inoculation.
(A) Flow cytometry analysis of epidermis-infiltrating CD4 T cells and γδ T cells in topical inoculation of S. aureus on WT, Flg−/− and Flg−/− Langerin-DTA mice (N=6). (B, C) Area of inflamed lesions and epidermis-infiltrating γδ T cells of WT, Flg−/− and Flg−/− Langerin-DTA mice inoculated with S. aureus via occlusive dressing technique. The data are shown as the mean ± SD. *P<0.05, **P<0.01 determined by Student’s t test. See also Figure S7.