Skip to main content
. Author manuscript; available in PMC: 2016 Jan 16.
Published in final edited form as: ACS Chem Biol. 2015 Jan 16;10(1):95–108. doi: 10.1021/cb500846u

Figure 1. Proposed model for fatty acid stimulation of SIRT6 activity.

Figure 1

SIRT6-dependent deacetylation is stimulated by free long-chain fatty acids obtained through diet or from fasting, which leads to increased transcriptional repression and downregulation of glycolytic and lipogenic genes.