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. Author manuscript; available in PMC: 2015 Apr 23.
Published in final edited form as: Future Microbiol. 2010 Aug;5(8):1185–1201. doi: 10.2217/fmb.10.91

Figure 3. GTPase cycle of large G proteins and points of toxin interactions.

Figure 3

ADP ribosylation of elongation factor (EF)-2 by DT or ExoA blocks interaction of GTP-bound EF-2 with the ribosome in the pretranslocation phase of the peptideelongation cycle, which prevents formation of the high-affinity complex and stimulation of the GAP activity of EF-2 by the ribosome. ADP ribosylation of EF-2 does not interfere with GTP or GDP binding to EF-2, but may inhibit the exchange of GDP with GTP.

DT: Diphtheria toxin; GAP: GTPase activating protein; GEF: Guanine nucleotide exchange factor.