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. 2014 Nov 24;64(5):1532–1543. doi: 10.2337/db14-0827

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© 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

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Effects of exercise and caloric restriction on lipid-derived acylcarnitine and acyl-CoA metabolites in NT and MCK-PGC1α mice fed an HFD. Lipid metabolites were measured by tandem mass spectrometry using gastrocnemius muscles from NT and MCK-PGC1α mice after 30 weeks of high-fat feeding without or with exercise and caloric restriction (Ex/CR). A: Free carnitine and acetylcarnitine. B: Even-chain acylcarnitines. C: Free CoA and acetyl-CoA. D: Even-chain acyl-CoAs. Data represent means ± SEM for 6–8 mice per group. Statistical differences were analyzed by two-way ANOVA. There was an effect of treatment group on free carnitine, acylcarnitine, and acyl-CoA levels. *P < 0.05 between genotypes, #P < 0.05 within a genotype between treatment conditions (sedentary [Sed] versus Ex/CR).