Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 21;15:34. doi: 10.1186/s12894-015-0030-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Hypolite et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Concentration dependent effects of PKC stimulation by PDBu on spontaneous contractions of isolated detrusor strips. A, Spontaneous contractile activity of DSM strips upon increasing concentrations of PDBu (0–640 nM). At the initial concentration of 20 nM, PDBu inhibited spontaneous contractions, and caused a small but significant decrease in the baseline BSM tone. Continued application of PDBu reversed this decline and increased the muscle force above the initial basal levels. B, Summarized maximal amplitude of contractions indicates that PDBu significantly reduced PF generation (peak force, PF) at lower PDBu concentrations (20-40 nM; N = 5, n = 7 in each group, p < 0.05 to baseline).