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. 2015 Apr 21;15:34. doi: 10.1186/s12894-015-0030-9

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© Hypolite et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Urodynamic recordings from non-anesthetized rats upon intravesical instillation of low and high PDBu. A, Representative traces of intravesical pressure (top panel) and voided volume (lower panel) in rats instilled with low concentration of PDBu (50 nM). B, Representative traces of intravesical pressure (top panel) and voided volume (lower panel) in rats instilled with high concentration of PDBu (1 μM). C, Perfusion of the urinary bladder in vivo with low PDBu did not affect the voided volume (C) nor the number of voids (D). However, high concentration of PDBu caused a significant increase in the frequency of micturition contractions (B; upper panel), and a decrease in voided volume (B; lower panel) in unanesthetized rats.