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. 2015 Apr 21;15:34. doi: 10.1186/s12894-015-0030-9

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© Hypolite et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Urodynamic recordings showing the effect of PMA inhibitor, Ro318220, after intravesical instillation in vivo.A, Representative traces of intravesical pressure (top panel) and voided volume (lower panel) in a control rat instilled with saline. B, Representative traces of intravesical pressure (top panel) and voided volume (lower panel) in a rat instilled with Ro318220 (50 μM). C, Changes in voided volume after instillation with Ro318220. D, Number of non-voiding contractions after intravesical application of Ro318220 was increased from 2 ± 0.5 to 6 ± 1.1 over 1 h period. The decrease in voided volume was followed by a two-fold increase in frequency over the same time period (N = 4, p ≤ 0.05 to control group).