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. 2015 Apr 21;15:34. doi: 10.1186/s12894-015-0030-9

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© Hypolite et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Contractile responses of the detrusor muscle strips to EFS upon application of PKC inhibitor, Bim-1. Muscle strips were pre-incubated with different concentrations of Bim-1 (4-32 nM) for 60 min prior to EFS-induced nerve stimulation. A, The upper panel shows the contractile tracers of control strips at tested frequencies, and the lower panels represent BSM contractility after Bim-1 treatments. EFS was carried out at 0.5-32 Hz. B, Summarized integral force (IF, g/s, n = 5 for each group) of BSM responses to Bim-1. Incubation with Bim-1 caused a significant reduction in IF upon 4 Hz and higher frequencies of EFS-induced contraction (N = 3, n = 5, p ≤ 0.05 to control for 16-32 μM of Bim-1).