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. 2015 Apr 21;15:34. doi: 10.1186/s12894-015-0030-9

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© Hypolite et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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High level of PKC activation increases sensitivity of BSM strips to low frequency of EFS. A, Upper panel shows the response of the control strip to increasing frequencies of EFS whereas the lower panel represents the frequency-response curve after incubation with PDBu (1 μM). B, PDBu caused a significant leftward shift (open circles) in BSM sensitivity to EFS representative of a 5-fold increase in muscle responsiveness to EFS in the presence of high PDBu concentration (N = 5,n = 6, p ≤ 0.05).