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. 2015 Mar 31;17(1):48. doi: 10.1186/s13058-015-0552-9

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© Campbell et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunization of HER2/neu-transgenic mice with Hp91 in nanoparticles delayed tumor development and prolonged survival. At 2 months of age, mice were immunized with 5 μg HER2 peptide in PBS, 25 μg of Hp91 free peptide, or 25 μg Hp91 delivered in PLGA-NPs. After final immunization, mice were monitored twice a week for tumor growth and survival. (A) Percentages of tumor-free mice were calculated as cumulative number of mice with tumor and mice that were tumor free. (B) Mice were sacrificed once tumor masses exceeded 1.5 cm mean diameter. HER2, human epidermal growth factor receptor 2; PBS, phosphate-buffered saline; PLGA-NPs, poly(D,L-lactic-co-glycolic) acid nanoparticles.