Table 2. The DE genes associated with immune and inflammatory responses in H1N1 group.
| Functional classification | Description | Gene symbol | Gene ID | Fold change |
|---|---|---|---|---|
| Immune response | complement component 6 | C6 | 100037952 | 2.66 |
| toll-like receptor 3 | TLR3 | 100037937 | -2.54 | |
| ring finger protein 125, E3 ubiquitin protein ligase | RNF125 | 100517591 | 2.19 | |
| CD59 molecule, complement regulatory protein | CD59 | 397347 | 2.00 | |
| CD1d molecule | CD1D | 100124526 | -1.93 | |
| chemokine (C-C motif) receptor-like 1 | CCRL1 | 100037292 | 1.86 | |
| peroxidasin homolog (Drosophila) | PXDN | 100516076 | 1.72 | |
| Rep:CD274 molecule CD274, mRNA- Homo sapiens | CD247 | 397302 | 1.71 | |
| lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | LCP2 | 100511843 | 1.70 | |
| toll-like receptor 1 | TLR1 | 396607 | 1.65 | |
| GTP binding protein overexpressed in skeletal muscle | GEM | 404772 | -1.63 | |
| CD4 molecule | CD4 | 404704 | 1.58 | |
| toll-like receptor 6 | TLR6 | 396621 | 1.58 | |
| Inflammatory response | sphingosine-1-phosphate receptor 3 | S1PR3 | 100154607 | 2.29 |
| Rep: transforming growth factor, beta 2- Macaca mulatta | TGFB2 | 397084 | -2.18 | |
| interleukin 17D | IL17D | 100738902 | 2.16 | |
| chemokine (C-C motif) ligand 2 | CCL2 | 397422 | -1.99 | |
| interferon (alpha, beta and omega) receptor 1 | IFNAR1 | 396658 | 1.89 | |
| vascular endothelial growth factor C | VEGFC | 100127470 | -1.87 | |
| CD163 molecule | CD163 | 397031 | -1.84 | |
| interleukin 2 | IL2 | 396868 | 1.71 | |
| toll-like receptor adaptor molecule 2 | TICAM2 | 100520421 | 1.66 | |
| mitogen-activated protein kinase 12 | MAPK12 | 574062 | -1.65 | |
| chemokine (C-C motif) ligand 20 | CCL20 | 553951 | 1.61 | |
| chemokine (C-X-C motif) ligand 2 | CXCL2 | 414904 | 1.59 | |
| tumor necrosis factor receptor superfamily, member 1B | TNFRSF1B | 100037306 | 1.58 | |
| inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | IKBKG | 100127355 | -1.52 | |
| toll-interleukin 1 receptor (TIR) domain containing adaptor protein | TIRAP | 100514174 | -1.71 |
The DE genes associated with immune and inflammatory responses were assigned based on GO term and manual annotation. Manual annotations were listed in italics. Many genes with multiple functions were only listed in one category. Gene ID refers to NCBI gene ID in the study.