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. 2014 Apr 29;35(4):1152–1161. doi: 10.1111/liv.12558

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© 2014 The Authors. Liver International Published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fig 1 — OSTα-OSTβ mRNA levels are increased after 18 h of treatment with CDCA or hypoxia. After 18 h of treatment with 50 μM CDCA in DMSO and exposure to either normoxia or hypoxia, cells were harvested and mRNA levels were determined by TaqMan real-time PCR. Figures a–d show average results of at least three independent experiments, *P < 0.05, **P < 0.01. (a) Relative OSTα mRNA determined in Huh7 cells. All treatment combinations show significant upregulation of OSTα mRNA. (b) Relative OSTα mRNA determined in PHH. A significant upregulation of OSTα mRNA is seen under combined treatment conditions. (c) and (d) Significant upregulation of OSTβ mRNA is seen only with CDCA in both Huh7 cells (c) and PHH (d). In PHH, a significant increase in OSTβ mRNA was induced by hypoxia (d).