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The hepatic expression of HIF-1α and OSTα is significantly induced in rats suffering from chronic renal failure. Four sham-operated rats and four CRF rats that had undergone 5/6 nephrectomy were compared with regard to the expression level of HIF-1α and OSTα in hepatic tissue 8 weeks after the procedure. Western blot analysis shows a significant increase in both HIF-1α and OSTα under CRF conditions compared to sham-operated controls. Actin was probed for assay normalization.
