Table 4.
Changes in Anthropometric and Biochemical Variables Between Ezetimibe- and Placebo-Treated Patients
| Ezetimibe (n = 23) |
Placebo (n = 22) |
Difference | |||||
|---|---|---|---|---|---|---|---|
| Baseline | Posttreatment | P Value | Baseline | Posttreatment | P Value | (P Value) | |
| Weight (kg) | 93.0 ± 17.8 | 92.9 ± 18.7 | 0.8281 | 92.6 ± 19.6 | 92.0 ± 19.8 | 0.2808 | 0.2 (0.8079) |
| BMI (kg/m2) | 33.6 ± 5.2 | 33.2 ± 5.5 | 0.2225 | 33.6 ± 5.1 | 33.4 ± 5.0 | 0.2969 | −0.3 (0.4839) |
| ALT (IU/L) | 47.0 (29.0) | 48.0 (43.0) | 0.7682 | 45.5 (32.0) | 42.0 (14.0) | 0.5110 | 2.0 (0.6702) |
| AST (IU/L) | 33.0 (23.0) | 33.0 (36.0) | 0.9332 | 31.0 (34.0) | 32.0 (33.0) | 0.2124 | 1.0 (0.6004) |
| AST/ALT | 0.8 (0.6) | 0.8 (0.4) | 0.4065 | 0.8 (0.4) | 0.7 (0.4) | 0.4584 | 0.0 (0.9304) |
| Glucose (mg/dL) | 104.0 (25.0) | 99.0 (24.0) | 0.9500 | 108.5 (40.0) | 106.5 (24.0) | 0.6598 | −5.0 (0.8101) |
| Insulin (μU/mL) | 22.5 (13.0) | 26.5 (15.0) | 0.3787 | 24.5 (18.5) | 33.0 (19.0) | 0.0889 | −3.0 (0.5177) |
| Hemoglobin A1C (%) | 5.9 (0.6) | 5.9 (0.9) | 0.1699 | 6.1 (1.0) | 6.0 (0.8) | 0.5538 | 0.2 (0.1663) |
| Triglycerides (mg/dl) | 152.0 (63.0) | 125.0 (59.0) | 0.2139 | 144.5 (110.0) | 142.0 (107.0) | 0.3883 | −8.5 (0.0977) |
| Total Cholesterol (mg/dl) | 182.0 (26.0) | 152.0 (46.0) | 0.0003 | 169.0 (56.0) | 175.0 (37.0) | 0.3344 | −24.0 (0.0024) |
| LDL (mg/dL) | 99.0 (37.0) | 76.0 (30.0) | <0.0001 | 89.0 (53.0) | 90.5 (39.0) | 0.8048 | −20.0 (0.0019) |
| FFA (mmol/L) | 0.5 (0.3) | 0.5 (0.4) | 0.9765 | 0.7 (0.3) | 0.5 (0.3) | 0.0314 | 0.1 (0.1216) |
| Alkaline phosphatase (IU/L) | 74.0 (34.0) | 89.0 (45.0) | 0.0284 | 71.0 (39.0) | 70.5 (35.0) | 0.6139 | 6.0 (0.1255) |
| GGT (IU/L) | 44.0 (36.0) | 41.5 (38.0) | 0.5286 | 33.0 (38.0) | 36.5 (31.0) | 0.5523 | 3.0 (0.5069) |
| Total bilirubin (mg/dl) | 0.4 (0.4) | 0.4 (0.3) | 0.1088 | 0.4 (0.3) | 0.4 (0.2) | 0.8865 | 0.1 (0.1993) |
| Direct bilirubin (mg/dl) | 0.1 (0.0) | 0.1 (0.1) | 0.0547 | 0.1 (0.1) | 0.1 (0.0) | 0.6875 | 0.0 (0.1235) |
| HOMA-IR | 6.4 (4.5) | 6.4 (6.2) | 0.6502 | 6.5 (5.4) | 9.1 (5.2) | 0.6215 | 0.7 (0.8257) |
Data are expressed as median (interquartile range) with P values from Wilcoxon signed rank test or mean difference with P value in parentheses.
Abbreviations: BMI, body mass index; LDL, low-density lipoprotein; FFA, free fatty acids; GGT, gamma-glutamyl transferase; HOMA-IR, homeostatic model assessment of insulin resistance.